Fotodinamik Ve Fototermal Terapi İçin Geliştirilen Hidrojeller

Buluş, ilaç ve medikal alanlarda tedavi veya canlı yaşamı ile ilgili bilimsel çalışmalarda kullanımı olan Fotodinamik Ve fototermal terapi için geliştirilen hidrojeller olup, özelliği; temel olarak 2- methylbenzo[d]thiazol-5-yl undec-10-enoate (3A), 2,3- dimethyl-5-(undec-10-enoyloxy)benzo[d]thiazol-3-ium iodide (4A), (Z)-2-((E)-(3-methyl-5-(undec-10- enoyloxy)benzo[d]thiazol-2(3H)-ylidene)methyl)-4-((3- methyl-5-(undec-10-enoyloxy)benzo[d]thiazol-3- ium-2- yl)methylene)-3-oxocyclobut-1-en-1-olate, (Sq1A), (Z)-2 -((E)-(5-(((13R)-11-((S)-2-isobutyramidopropyl)-14- (isopropylamino)-13-methyl-14-oxotetradecanoyl)oxy)-3 -methylbenzo[d]thiazol- 2(3H)-ylidene)methyl)-4-((5- (((S)-13-(isopropylamino)-10-((S)-3-(isopropylamino)-2- methyl-3-oxopropyl)-12-methyl-13- oxotridecanoyl)oxy)- 3-methylbenzo[d]thiazol-3-ium-2-yl)methylene)-3- oxocyclobut-1-en-1-olate, (MPA1A), 5-metoksi-2,3,3- trimetil-3H-indol (3B), 2,3,3-trimetil-3H-indol-5-ol (4B), 2,3,3-trimetil-3H-indol-5-yl undek-10-enoat (6B), 1,2,3,3 -tetrametil-5-(undek-10-enoiloksi)-3H-indol-1-ium iodid (7B), (Z)-3-okso-4-((1,3,3-trimetil-5-(undek-10- enoyiloksi)-3H-indol-1-ium-2-il)metilen)-2-(((Z)-1,3,3- trimetil-5-(undek-10-enoiloksi)indolin-2- ilidene)metil)siklobut-1-en-1-olat, iodid salt (Sq1B) ve (Z)-4-((5-(((12S)-13-(isopropylamino)-10-((R)-3- (isopropylamino)-2-methyl-3-oxopropyl)-12-methyl-13- oxotridecanoyl)oxy)-1,3,3-trimethyl-3H-indol-1-ium-2- yl)methylene)-2-(((Z)-5-(((R)-13-(isopropylamino)-10- ((R)-3-(isopropylamino)-2-methyl-3-oxopropyl)-12- methyl-13-oxotridecanoyl)oxy)-1,3,3-trimethylindolin-2- ylidene)methyl)-3-oxocyclobut-1-en-1-olate, iodide salt (MPA1B) sentezlerinden oluşmasıdır. TR 2021 005179 A2