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European Patent (TR Translation)

Yüksek Afiniteli Sırp-Alfa Reaktifleri.

Invention Abstract

(i)Yabani tip proteine kıyasla en az bir adet amino asit değişikliği içeren ve (ii) yabani tip proteine kıyasla CD47'ye yönelik daha yüksek bir afiniteye sahip olan yüksek afiniteli SIRP-α reaktifleri ortaya koyulmaktadır. SIRPα ile ligandı CD47 arasındaki fizyolojik bağlanma etkileşimini bloke eden bir yüksek afiniteli SIRPα reaktifinin yer aldığı bir farmasötik bileşimin bir terapötik dozunu uygulamak suretiyle bir memelide fagositozu modüle etmek için olan bileşimler ve yöntemler de ortaya koyulmaktadır.

IPC Classes
C07K14/47C12N9/16A61K38/16C07K16/28G01N33/50
Parties
Inventor
Irvıng L Weıssman 747 Santa Ynez Street Stanford, Ca 94305 A.B.D. Aron M Levın 5 Faınwood Cırcle Cambrıdge, Ma, 02139 A.B.D. Aaron Mıchael Rıng 2253 Wıllıams Street Palo Alto, Calıfornıa 94306 A.B.D. Kenan Chrıstopher Garcıa 580 Kenwood Drıve Menlo Park, Ca 94025 A.B.D. Kıpp Andrew Weıskopf 745 Menlo Avenue Unıt 10 Menlo Park, Ca 94025 A.B.D.
Rights Holder
The Board Of Trustees Of The Leland Stanford Junıor Unıversıty Offıce Of The General Counsel Buıldıng 170, Thırd Floor, Maın Quad P.O. Box 20386 Stanford, Ca 94305-2038 A.B.D.
Attorney
Nükhet Serra Coral (Deriş Patent Ve Marka Acentalığı A.Ş.) İnebolu Sok. Deriş Patent Binası No:5 Kabataş/ Setüstü 80040/İstanbul

This record is compiled from official TPMK patent bulletins and is provided for information. The abstract text is as published, in Turkish. The current legal status (opposition, assignment, invalidation) requires a full register review. Ask our experts for a comprehensive patent search.